Research

Our research focuses on understanding the molecular mechanisms of obesity and Type 2 diabetes. Specifically, we investigate how diet changes epigenetic phenomena (e.g. Histone modification, DNA methylation), thereby regulating the expression of genes associated with body weight regulation and energy metabolism. Our goal is to develop pharmaceutical and nutritional strategies for the prevention and treatment of obesity and Type 2 diabetes.  

Using rodent and cell culture models, we investigate: 

1) Epigenetic regulation of signaling pathways of metabolic hormones that control body weight such as leptin, insulin, and GLP-1. 

2) The effect of various diets (high-calorie diets, calorie restriction, and single nutrients) on the expression of genes related to appetite control and energy expenditure. 

3) The effect of maternal nutritional status on the metabolic health of offspring.